AI4OPT aims at revolutionizing how health care is delivered for patients with dementia, from triage to diagnosis and care delivery. AI will play an increasing role in addressing the challenges of an aging population and ensuring that brain diseases are diagnoses early, which is requirement to maximize the impact of new medications. AI4OPT adopts a system engineering approaches to this brain health care, leveraging AI and Digital Twin technology to cope with the surge in demand in this domain.